Since 1997 he has been a consultant theologian of the National Service for the Cultural Project of the Italian Episcopal Conference (CEI). As of 2022 he was he a member of the International Council for Catechesis (COINCAT) and of the Commission for Culture and Social Communication of the CEI. Within the Sicilian Episcopal Conference he is a delegate for migrants. He was director and a teacher at the Instituto Teologico Calabro. He also taught at the Theological Faculty of Southern Italy in Naples and the Institute of Religious Science of Crotone. He taught theology at the Pontifical Gregorian University and Pontifical Urban University. He was appointed "adiutor secretarii specialis" in the General Assembly of the Synod of Bishops 2–23 October 2005. He is also adjunct lecturer with the LUMSA University in Rome, Italy with the department of law, economics, politics, foreign languages and human sciences; and has written several theological publications in this regard. Pope Francis appointed Staglianò president of the Pontifical Academy of Theology on 6 August 2022, and also on September 23, 2024 as one of the 28 new consultors of the Dicastery for the Doctrine of the Faith.